Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO

This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock. An individualized transfusion strategy based on ScVO2 level, is compared to a conventionnal strategy based on predefined hemoglobin threshold. The primary endpoint is the consumption of packed red blod cells, secondary endpoints are subgroup analysis, mortality, morbidity, and cost-effectiveness

NCT Number	NCT05699005
Lead Sponsor	University Hospital, Lille Collaborators: Amiens University Hospital, University Hospital, Caen, University Hospital, Rouen, Centre Hospitalier Universitaire Dijon, Centre Hospitalier de Lens
Conditions	Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia, Oxygen Delivery
Enrollment	236 participants
Start Date	2023-09-18
Primary Completion	2028-03-18 (estimated)
Study Completion	2028-12-18 (estimated)
Updated on ClinicalTrials.gov	2026-07-02