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Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects

StatusRecruiting
PhasePhase 2/3
Started2023-10-17
View on ClinicalTrials.gov ↗

Amendment history

2026-03-16
Study Status, Oversight v6
Primary completion date2026-02→2027-02-01
Completion date2027-02→2028-02-01
2025-03-20
Study Status, Oversight, Arms and Interventions, Eligibility, Contacts/Locations v5
Study arms3→4
Eligibility criteria+136 characters
Inclusion Criteria: Both Sexes Age: younger lean group 18-30 years with BMI 18.5-24.9 kg/m2; younger obese group 18-30 with BMI 30.0 -39.9; older leanobese group ≥ 65 years with BMI 30.0-39.9 All races and ethnic groups Community dwelling Sedentary (≤ [...] r 1.5 ounces [45ml] of hard liquor) or recreational drug use (other than marijuana) Pregnant or breastfeeding Postmenopausal women new (within [...] History of allergy to dasatinib, quercetin and/or lidocaine. Concurrent enrollment in another interventional trial.
Study sitescontacts updated at 1 of 1 site
2024-01-12
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v4
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2023-09→confirmed 2023-10-17
Study sites0→1
2023-09-14
Study Identification, Study Status, Sponsor/Collaborators, Study Design, Eligibility v3
PhaseEarly Phase 1→Phase 2/3
Start date2023-08→2023-09
Enrollment target120→160
Lead sponsorThe University of Texas Health Science Center at San Antonio→Cedars-Sinai Medical Center
Eligibility criteria+17 characters
[...] exercise/week Unstable weight (>3% change in last 3 months) CompromisedNeurological, musculoskeletal function, includingor pain,other weakness,conditions stiffness,that jointmay noiseslimit subject's ability to complete study physical assessment and decreased range of motiontraining Active autoimmune/inflammatory disease including: rheumatoi [...]
2023-04-20
Study Status v2
Start date2023-03→2023-08
2023-03-20
Study Identification, Study Status, Sponsor/Collaborators, Eligibility v1
Start date2023-02→2023-03
Eligibility criteria-24 characters
Inclusion Criteria: 1) Both Sexes 2) Age: younger lean group 18-30 years with BMI 18.5-24.9 kg/m2; older lean group ≥ 65 years with BMI 2) All races and ethnic groups 3) Community dwelling 4) Sedentary (≤1.5 h of exercise per week) 5) Nondiabetic (fasting plasma glucose < 126 mg/dl, 2-h glucos [...] ral glucose tolerance test (OGTT) < 140mg/dl, and A1c < 6.5% 6) For all female participants who are women of childbearing p [...] either cervical cap, diaphragm, or sponge with spermicide. 7) ECG value after 10 minutes of resting in the supine position [...]
Collaborators+33 characters
National Institute on Aging (NIA)
Study title-1 characters
Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects.
2022-12-07
Original filing
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo (n=24).
Trial Details
NCT Number NCT05653258
Lead Sponsor Cedars-Sinai Medical Center
Collaborators: National Institute on Aging (NIA)
Conditions Obesity, Healthy Lifestyle
Enrollment 160 participants
Start Date 2023-10-17
Primary Completion 2027-02-01 (estimated)
Study Completion 2028-02-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-18