Clinical Trial

Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects

Recruiting Phase 2/3
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Summary
All participants will undergo baseline biopsies of subcutaneous abdominal adipose tissue for cellular/molecular profiling via snRNA-seq and metabolic/physiological assessments (insulin sensitivity, glucose tolerance, and β-cell function). Older obese participants will be randomized into three arms: lifestyle intervention (n=24), senolytics (n=24), or placebo (n=24).
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2022-12-07; most recent amendment 2026-03-16.
Status change: Not Yet Recruiting → Recruiting 2024-01-12
Trial Details
NCT Number NCT05653258
Lead Sponsor Cedars-Sinai Medical Center
Collaborators: National Institute on Aging (NIA)
Conditions Obesity, Healthy Lifestyle
Enrollment 160 participants
Start Date 2023-10-17
Primary Completion 2027-02-01 (estimated)
Study Completion 2028-02-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-18