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NCT05642455 · ClinicalTrials.gov record · last posted 2026-08-11

SPEARHEAD-3 Pediatric Study

Name: SPEARHEAD-3 Pediatric Study — clinical trial record (NCT05642455)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusRecruiting

PhasePhase 1/2

SponsorUSWM CT, LLC

Started2023-09-01

View on ClinicalTrials.gov ↗

from the ClinicalTrials.gov record

This is a pediatric basket study to investigate the safety and efficacy of afamitresgene autoleucel in HLA-A\*02 eligible and MAGE-A4 positive subjects aged 2-17 years of age with advanced cancers.

Amendment record 10 amendments on the ClinicalTrials.gov record

This ClinicalTrials.gov record has been amended 10 times since 2022-12-06; most recent amendment 2026-02-05. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history. See every version on ClinicalTrials.gov ↗

2024-02-15

Status change Not Yet Recruiting→Recruitingv5

Trial Details

NCT Number	NCT05642455
Lead Sponsor	USWM CT, LLC
Conditions	Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST), Neuroblastoma (NBL), Osteosarcoma
Enrollment	20 participants
Start Date	2023-09-01
Primary Completion	2026-10-01 (estimated)
Study Completion	2038-07-30 (estimated)
Updated on ClinicalTrials.gov	2026-08-11