The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death. Patients with heart disease undergoing major surgery are at increased risk of complications after surgery, including heart attack, stroke, and death. The proposed research seeks to better understand the role of inflammation in the damage to the heart and blood vessels after major surgery. This research also seeks to identify the potential beneficial role of a safe medication, colchicine, which has direct effects on inflammatory cells and has been used in the treatment of inflammatory diseases for more than 2000 years, on reducing the rate of complications after surgery. With its quick onset of action and excellent safety profile, colchicine may have the potential to reduce risk of heart injury, stroke, or death after major surgery.

NCT Number	NCT05618353
Lead Sponsor	VA Office of Research and Development Collaborators: NYU Langone Health
Conditions	Coronary Artery Disease
Enrollment	700 participants
Start Date	2023-08-21
Primary Completion	2028-07-31 (estimated)
Study Completion	2029-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-22