Clinical Trial

Evaluating the Safety and Efficacy of a Novel Accelerated Partial Breast Irradiation Regimen

Study acronym: APBI RISE
Active, Not Recruiting Phase 2
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Summary
This study will use an adjuvant radiation therapy regimen called APBI (accelerated partial breast irradiation). APBI is a treatment option available to women considered to have an early stage, low-risk breast cancer. The standard external beam-based APBI treatment delivers treatments every other day for five treatments, over ten calendar days. The APBI in this study is modified and will deliver five once daily treatments over consecutive treatment days, with a slightly lower dose of radiation each day as compared to the standard external beam-based APBI treatment.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2022-10-19; most recent amendment 2026-05-05.
Status change: Recruiting → Active, Not Recruiting 2025-02-06
Trial Details
NCT Number NCT05591547
Lead Sponsor Sanford Health
Collaborators: University of North Dakota
Conditions Breast Cancer
Enrollment 91 participants
Start Date 2022-03-30
Primary Completion 2027-06 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2026-05-06