Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication

This is an open-label pilot trial to assess the safety and feasibility of a novel 8-week psilocybin-assisted psychotherapy intervention to facilitate successful tapering/discontinuation of opioid pain medication in adult patients receiving long-term opioid therapy for chronic pain. Participation will last approximately 8 months and includes one or two psilocybin-assisted therapy sessions. The study will evaluate the incidence and severity of adverse events during and after treatment, the number of participants who drop out of the study for intervention-related reasons, and the self-reported benefits and harms of the intervention.

NCT Number	NCT05585229
Lead Sponsor	University of British Columbia Collaborators: Etheridge Foundation
Conditions	Opioid Dependence, Chronic Pain
Enrollment	10 participants
Start Date	2025-10-27
Primary Completion	2026-08-31 (estimated)
Study Completion	2026-08-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-04