Clinical Trial

Natural History of PRPF31 Mutation-Associated Retinal Dystrophy

Active, Not Recruiting
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Summary
The purpose of this study is to characterize the natural history through temporal systemic evaluation of subjects identified with PRPF31 mutation-associated retinal dystrophy, also called retinitis pigmentosa type 11, or RP11. Assessments will be completed to measure and evaluate structural and functional visual changes including those impacting patient quality of life associated with this inherited retinal condition and observing how these changes evolve over time.
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2022-10-05; most recent amendment 2026-04-07.
Status change: Recruiting → Active, Not Recruiting 2025-03-11
Trial Details
NCT Number NCT05573984
Lead Sponsor PYC Therapeutics
Conditions Retinitis Pigmentosa, Eye Diseases, Hereditary, Retinal Dystrophies, Retinal Dystrophy Rod, Retinal Dystrophy Rod Progressive
Enrollment 50 participants
Start Date 2022-07-07
Primary Completion 2026-09-09 (estimated)
Study Completion 2026-11-01 (estimated)
Updated on ClinicalTrials.gov 2026-04-13