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Natural History of PRPF31 Mutation-Associated Retinal Dystrophy

StatusActive, Not Recruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated April 13, 2026 (before its estimated September 9, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: Feb 28, 2026 to Sep 9, 2026
    • Study completion date: Feb 28, 2026 to Nov 1, 2026
    v9
  2. Trial status: Recruiting to Active, Not Recruiting
    • Primary completion date: Dec 31, 2026 to Feb 28, 2026
    • Study completion date: Apr 30, 2027 to Feb 28, 2026
    • Site details revised at 7 of 7 sites
    v8
  3. Site details revised at 1 of 7 sitesv7
  4. Re-verified, no change to tracked fieldsv6
  5. Study sites: 6 to 7v5
Show 3 earlier versionsHide 3 earlier versions
  1. Site details revised at 4 of 6 sitesv4
  2. Site contacts updated at 1 of 6 sitesv3
  3. Study sites: 5 to 6v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to characterize the natural history through temporal systemic evaluation of subjects identified with PRPF31 mutation-associated retinal dystrophy, also called retinitis pigmentosa type 11, or RP11. Assessments will be completed to measure and evaluate structural and functional visual changes including those impacting patient quality of life associated with this inherited retinal condition and observing how these changes evolve over time.
Trial Details
NCT Number NCT05573984
Lead Sponsor PYC Therapeutics
Conditions
(from sponsor)		 Retinitis Pigmentosa, Eye Diseases, Hereditary, Retinal Dystrophies, Retinal Dystrophy Rod, Retinal Dystrophy Rod Progressive
Related terms Eye Diseases, Hereditary, Retinal Dystrophies, Retinitis Pigmentosa
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov