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Effects of Psilocybin in Obsessive Compulsive Disorder

StatusActive, Not Recruiting
PhaseEarly Phase 1
Started2022-11-28
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Sep 12, 2026 → Dec 30, 2026
See other at-risk trials from Johns Hopkins University

Amendment history

2026-09-03
Study Status v11
Primary completion pushed: 2026-09-12 → 2026-12-30
2026-04-01
Study Status, Study Design v10
Enrollment target34→35
2026-03-25
Recruiting→Active, Not Recruiting Study Status, Study Design, Contacts/Locations v9
Trial statusRecruiting→Active, Not Recruiting
Enrollment targetestimated 30→confirmed 34
Study sitesdetails revised at 1 of 1 site
2025-11-06
Study Status, Eligibility, Contacts/Locations v8
Re-verified, no change to tracked fields
2025-09-10
Study Status v7
Primary completion date2025-09-12→2026-09-12
Completion date2026-09-12→2027-09-12
Show 6 earlier versions
2025-05-12
Study Status, Sponsor/Collaborators v6
Collaborators+15 characters
Usona Institute
2024-05-28
3 amendments v3-v5
3 re-verifications since 2023-04-07, no change to tracked fields
2022-11-28
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2022-11-30→confirmed 2022-11-28
Study sites0→1
2022-11-04
Study Status v1
Start date2022-09-30→2022-11-30
2022-09-15
Original filing
This study will test the feasibility, safety, and evidence for efficacy of psilocybin administration in participants with obsessive compulsive disorder (OCD). This will serve as a preliminary proof of concept study for future larger studies aimed to investigate the utility, cognitive mechanisms, and neural correlates of this intervention.
Trial Details
NCT Number NCT05546658
Lead Sponsor Johns Hopkins University
Collaborators: Usona Institute
Conditions Obsessive-Compulsive Disorder
Enrollment 35 participants
Start Date 2022-11-28
Primary Completion 2026-12-30 (estimated)
Study Completion 2027-09-12 (estimated)
Updated on ClinicalTrials.gov 2026-09-04