Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries and Coronary Microvascular Dysfunction.

To demonstrate the feasibility and efficacy of the CS Reducer for the treatment of patients with ischaemia and non-obstructed coronary arteries (INOCA) and coronary microvascular dysfunction (CMD) and through a nested mechanistic substudy investigate the physiological responses in the coronary microcirculation responsible for changes in myocardial perfusion.

NCT Number	NCT05492110
Lead Sponsor	Imperial College London Collaborators: Bradford Teaching Hospitals NHS Foundation Trust, East and North Hertfordshire NHS Trust, Epsom and St Helier University Hospitals NHS Trust, Guy's and St Thomas' NHS Foundation Trust, Imperial College Healthcare NHS Trust, Kingston Hospital NHS Trust, London North West Healthcare NHS Trust, Oxford University Hospitals NHS Trust, Royal Brompton & Harefield NHS Foundation Trust, St George's University Hospitals NHS Foundation Trust, Liverpool University Hospitals NHS Foundation Trust, East Kent Hospitals University NHS Foundation Trust
Conditions	Refractory Angina, Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Disease, Angina Pectoris, INOCA (Ischemia With Non Obstructive Coronary Artery Disease), ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Enrollment	54 participants
Start Date	2023-04-17
Primary Completion	2026-08-04 (estimated)
Study Completion	2026-08-05 (estimated)
Updated on ClinicalTrials.gov	2026-08-12