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Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)

Study acronym: IDEALSepsisI
StatusRecruiting
PhasePhase 1
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated March 3, 2026 (before its estimated May 28, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: Apr 2025 to May 28, 2026 Completion date: Sep 2025 to Sep 30, 2026v9 Show 1 more changeShow less
    • Completion date: Sep 2025 to Sep 30, 2026
  2. Trial status: Active, Not Recruiting to Recruiting Site details revisedv8 Show 1 more changeShow less
    • Site details revised
  3. Trial status: Recruiting to Active, Not Recruiting Site details revisedv7 Show 1 more changeShow less
    • Site details revised
  4. Trial status: Active, Not Recruiting to Recruiting Site details revisedv6 Show 1 more changeShow less
    • Site details revised
  5. Trial status: Not Yet Recruiting to Active, Not Recruiting Study sites: 0 to 1 · Start date changed from estimate of Apr 2023 to Jan 17, 2023v5 Show 2 more changesShow less
    • Study sites: 0 to 1
    • Start date changed from estimate of Apr 2023 to Jan 17, 2023
Show 3 earlier versionsHide 3 earlier versions
  1. Re-verified, no change to tracked fieldsv4
  2. Start date: Oct 2022 to Apr 2023v3
  3. Start date: Jul 2022 to Oct 2022v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Phase I dose-escalation safety and feasibility of IV DNase I in ICU septic patients.
Trial Details
NCT Number NCT05453695
Lead Sponsor McMaster University
Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions Sepsis, Critical Illness
Enrollment 36 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov