Clinical Trial

Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

Active, Not Recruiting Phase 3

Summary

This phase III trial compares the usual treatment of surgery after stereotactic radiosurgery (SRS) to receiving SRS before surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation to target tumors and minimizes effect on normal surrounding brain tissue. The combination of surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases. This study investigates whether treating with SRS before surgery may be better than SRS after surgery in reducing the possibility of the tumor coming back, reducing or preventing the cancer from spreading to other areas of the brain and reducing the risk of scarring on the brain from radiation.

Protocol Amendment History 20 amendments

This ClinicalTrials.gov record has been amended 20 times since 2022-06-24; most recent amendment 2026-05-18.

Status change: Recruiting → Active, Not Recruiting 2025-10-23

Status change: Not Yet Recruiting → Recruiting 2022-10-05

Trial Details

NCT Number	NCT05438212
Lead Sponsor	NRG Oncology Collaborators: National Cancer Institute (NCI)
Conditions	Metastatic Malignant Neoplasm in the Brain
Enrollment	237 participants
Start Date	2022-10-24
Primary Completion	2027-03-16 (estimated)
Study Completion	2027-03-16 (estimated)
Updated on ClinicalTrials.gov	2026-05-19