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Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Completion pushed from Mar 16, 2027 to Mar 16, 2032v22
  2. 2 versions Re-verified since May 5, 2026, no change to tracked fieldsv20-v21
  3. Study sites: 215 to 216v19
  4. Study sites revised (215)v18 See this version in full on ClinicalTrials.gov ↗
  5. Study sites: 214 to 215v17
Show 15 earlier versionsHide 15 earlier versions
  1. Trial status: Recruiting to Active, Not Recruiting Enrollment target: estimated 236 to confirmed 237 · Study sites: 215 to 214v16 Show 2 more changesShow less
    • Enrollment target: estimated 236 to confirmed 237
    • Study sites: 215 to 214
  2. Study sites: 213 to 215v15
  3. Study sites: 191 to 213v14
  4. Study sites: 187 to 191v13
  5. Start date: Aug 31, 2022 to Oct 24, 2022 Study sites: 180 to 187 · Completion date: Mar 16, 2032 to Mar 16, 2027 · Secondary endpoints revised (8) · 3 morev12 Show 6 more changesShow less
    • Study sites: 180 to 187
    • Completion date: Mar 16, 2032 to Mar 16, 2027
    • Secondary endpoints revised (8)
    • Primary endpoint revised
    • Eligibility criteria shortened, about 4 words
    • Study description expanded, about 1 word

    See this version in full on ClinicalTrials.gov ↗

  6. Study sites: 161 to 180v11
  7. Study sites: 105 to 161v10
  8. Study sites: 90 to 105v9
  9. Study sites: 84 to 90v8
  10. Study sites: 81 to 84v7
  11. Study sites: 54 to 81v6
  12. Study sites: 3 to 54v5
  13. Eligibility criteria expanded, about 2 wordsv4 See this version in full on ClinicalTrials.gov ↗
  14. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 3v3 Show 1 more changeShow less
    • Study sites: 0 to 3
  15. Start date: Feb 3, 2023 to Aug 31, 2022v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
NRG Oncology
67 trials monitored
See 5 trials at risk
This phase III trial compares the usual treatment of surgery after stereotactic radiosurgery (SRS) to receiving SRS before surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation to target tumors and minimizes effect on normal surrounding brain tissue. The combination of surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases. This study investigates whether treating with SRS before surgery may be better than SRS after surgery in reducing the possibility of the tumor coming back, reducing or preventing the cancer from spreading to other areas of the brain and reducing the risk of scarring on the brain from radiation.
Trial Details
NCT Number NCT05438212
Lead Sponsor NRG Oncology
Collaborators: National Cancer Institute (NCI)
Conditions Metastatic Malignant Neoplasm in the Brain
Enrollment 237 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov