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Decoding and Modulating Affective Brain States

StatusRecruiting
PhaseNot applicable
Started2023-02-21
View on ClinicalTrials.gov ↗
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.

Amendment history 2 changes detected by DataLookout

2026-09-04
Primary completion pushed: 2027-12-01 → 2028-12-01
2026-09-04
Completion pushed: 2028-12-01 → 2029-12-01
Trial Details
NCT Number NCT05437705
Lead Sponsor University of Pennsylvania
Conditions Rumination, Major Depressive Disorder, Anxiety
Enrollment 40 participants
Start Date 2023-02-21
Primary Completion 2028-12-01 (estimated)
Study Completion 2029-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-03