Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients

The INTACT-HIP trial study will evaluate feasibility of conducting a randomized, double-blinded controlled trial comparing postoperative treatment with intravenous (IV) acetaminophen versus oral acetaminophen, in older adults undergoing hip fracture surgery. The results of this feasibility trial will be used to inform designing a larger, multi-center, randomized controlled trial to assess the efficacy of IV acetaminophen compared to oral acetaminophen to reduce delirium and improve other clinical and patient-centered outcomes after hip fracture surgery. It will randomize 42 older adults to receive either oral or IV acetaminophen after hip fracture surgery.

NCT Number	NCT05425355
Lead Sponsor	University Health Network, Toronto
Conditions	Hip-fracture, Surgery
Enrollment	42 participants
Start Date	2023-01-23
Primary Completion	2026-08-30 (estimated)
Study Completion	2026-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-23