Clinical Trial

AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip

Study acronym: REPAIR

Recruiting Phase 1

Record status

This record was last updated September 24, 2025 (before its estimated January 1, 2026 completion). Its status may not reflect the trial's current state.

Summary

This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced chondrogenesis (AMIC) in comparison to microfracture on hip function, health-related quality of life, hip pain, cartilage regeneration, health utility, and any adverse events at 2 years. Follow-up will occur at 6 weeks, 6 months, 12 months, 18 months, and 24 months post-surgery.

Protocol Amendment History 3 amendments

This ClinicalTrials.gov record has been amended 3 times since 2022-05-27; most recent amendment 2025-09-22.

Status change: Not Yet Recruiting → Recruiting 2023-03-13

Trial Details

NCT Number	NCT05402072
Lead Sponsor	McMaster University Collaborators: Geistlich Pharma AG
Conditions	Hip Arthroscopy, Articular Cartilage Defect, Microfractures
Enrollment	40 participants
Start Date	2023-03-13
Primary Completion	2026-01-01 (estimated)
Study Completion	2027-01-01 (estimated)
Updated on ClinicalTrials.gov	2025-09-24