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Neural Mechanisms of Response Inhibition Training for OCRD

Study acronym: OCRD
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Aug 1, 2027 to Jul 31, 2027v7
  2. Primary completion date: Jul 2027 to Aug 1, 2027
    • Study completion date: Aug 2027 to Aug 31, 2027
    • Site contact updated
    v6
  3. Site contact updatedv5
  4. Re-verified, no change to tracked fieldsv4
  5. Start date changed from estimate of Nov 2022 to Dec 22, 2022v3
  6. Trial status: Not Yet Recruiting to Recruiting
    • Start date: Sep 2022 to Nov 2022
    • Study sites: 0 to 1
    v2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and/or skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.
Trial Details
NCT Number NCT05377125
Lead Sponsor University of Wisconsin, Milwaukee
Conditions
(from sponsor)		 Obsessive-Compulsive Disorder, Tricholemmoma, Skin-Picking
Related terms Excoriation Disorder, Obsessive-Compulsive Disorder, Trichotillomania
Enrollment 118 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov