Clinical Trial

Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD Trial

Active, Not Recruiting Phase 4
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Summary
Although there have been studies regarding intensive lowering of low-density lipoprotein (LDL)-cholesterol with high intensity statins in patients with cardiovascular disease, elderly patients were either excluded or accounted only a small portion of study subjects. Therefore, this study sought to compare the clinical outcomes according to the LDL-cholesterol therapy strategy (intensive targeting \[LDL-cholesterol goal of \<55mg/dL\] vs. conventional therapy \[moderate intensity statin therapy\]) in elderly patients with ≥75 years and documented cardiovascular disease.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2022-04-29; most recent amendment 2026-05-26.
Status change: Recruiting → Active, Not Recruiting 2026-05-26
Status change: Not Yet Recruiting → Recruiting 2022-10-07
Trial Details
NCT Number NCT05361421
Lead Sponsor Yonsei University
Conditions Cardiovascular Disease
Enrollment 1,200 participants
Start Date 2022-07-19
Primary Completion 2027-10-15 (estimated)
Study Completion 2027-10-15 (estimated)
Updated on ClinicalTrials.gov 2026-05-29