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Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay

Study acronym: SSL follow-up
StatusCompleted
PhaseNot applicable
Started2023-02-27
View on ClinicalTrials.gov ↗

Amendment history

2026-09-19
notable
Trial completed
2025-02-07
minor
Study Identification, Study Status, Study Description v3
Primary completion date2024-02-01→2025-12-31
Completion date2024-09-01→2025-12-31
Study description-2,733 characters
[...] luded HGD leading to high variability in reported outcomes. The primary aim of this study is to determine the rate of metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions [sessile serrated polyps (SSPs), traditional serrated adenomas (TSAs)], and metachronous high-risk adenoma (HRA) after index detection of high-grade dy [...] Patient with SL or HGD diagnosed from 2010-2022 will be gathered from the pathology department to determine which patients lack follow-up during these years. Patients with lack of follow-up will be contacted by phone, then invited to underg [...] [...]
Study titlerevised
EffectRisk of Metachronous Findings After Detection of Serrated PolypsLesions and High-grade Dysplasia atWith IndexSurveillance Colonoscopy on Risk of Metachronous High-risk AdenomasDelay
2023-12-14
minor
Study Status, Contacts/Locations v2
Primary completion date2023-09-01→2024-02-01
Completion date2023-12-01→2024-09-01
2023-03-08
notable
Not Yet Recruiting→Recruiting Study Identification, Study Status, Sponsor/Collaborators, Study Description, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2023-05-01→2023-09-01
Completion date2023-07-01→2023-12-01
Start dateestimated 2022-05-01→confirmed 2023-02-27
Study description-206 characters
[...] istopathology; complications, immediate and late (14 days). Endoscopy data will be recorded at the end of the procedures in CRFs and transferred by to a database. Telephone follow-up will be done 14 days after the procedure to report possible side effects occurred. We expect a higher percentage of high-risk lesions in our st [...]
Study sitesdetails revised at 1 of 1 site
2022-04-27
minor
Original filing
The primary aim of this study is to determine the rate of total metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions (SL) \[sessile serrated polyps (SSPs), traditional serrated adenomas (TSAs)\], and metachronous high-risk adenoma (HRA) after index detection of high-grade dysplasia (HGD). We will use the database of patients diagnosed with SL or HGD at index colonoscopy with a delay in surveillance and determine the risk of advanced lesions (especially high-risk lesion and CRC detection) of these delayed colonoscopies. The aim is to determine the effects of breach of continuity of care in these patients.
Trial Details
NCT Number NCT05355363
Lead Sponsor Centre hospitalier de l'Université de Montréal (CHUM)
Conditions Colorectal Cancer, Colon Adenoma
Enrollment 727 participants
Start Date 2023-02-27
Primary Completion 2025-12-31 (estimated)
Study Completion 2025-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-09-18