Neoadjuvant Systemic and Peritoneal Chemotherapy for Advanced Gastric Cancer

Data demonstrating the efficacy of PIPAC in patients with regionally advanced gastric cancer with positive peritoneal cytology and/or minimal peritoneal disease is limited due to the relatively recent development of this technique and its historical preferential use in palliative patients with disseminated peritoneal metastasis. Existing data suggest PIPAC administered every six weeks in conjunction with standard treatment may work as an adjunct to conventional systemic neoadjuvant chemotherapy. PIPAC protocols have been established both for gastric cancer as well as other intra-abdominal malignancies and have a good safety profile. Given these promising findings, a study protocol is proposed herein to further investigate PIPAC for the treatment of a highly selected group of patients with regionally advanced gastric cancer (positive peritoneal cytology and/or minimal peritoneal disease).

NCT Number	NCT05318794
Lead Sponsor	Imperial College London
Conditions	Gastric Cancer, Peritoneal Metastases, Chemotherapy Effect
Enrollment	20 participants
Start Date	2023-11
Primary Completion	2025-07 (estimated)
Study Completion	2030-07 (estimated)
Updated on ClinicalTrials.gov	2023-09-13