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Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 6 months later Jun 30, 2026 → Dec 31, 2026
See other at-risk trials from Massachusetts General Hospital

Record History

  1. Primary and study completion pushed from Jun 30, 2026 to Dec 31, 2026 Enrollment closed, study ongoing · Secondary endpoints: details revised at 1 of 1 entry · Site details revised · 1 more Show 4 more changesShow less
    • Enrollment closed, study ongoing
    • Secondary endpoints: details revised at 1 of 1 entry
    • Site details revised
    • Eligibility criteria expanded, about 4 words
  2. Re-verified, no change to tracked fieldsv8
  3. Lead sponsor: Boston Children's Hospital to Massachusetts General Hospital Primary and study completion dates: Feb 2027 to Jun 30, 2026 · Study site revisedv7 Show 2 more changesShow less
    • Primary and study completion dates: Feb 2027 to Jun 30, 2026
    • Study site revised

    See this version in full on ClinicalTrials.gov ↗

  4. Enrollment target: 420 to 110v6
  5. Re-verified, no change to tracked fieldsv5
Show 3 earlier versionsHide 3 earlier versions
  1. Eligibility criteria expanded, about 63 wordsv4 See this version in full on ClinicalTrials.gov ↗
  2. Study description expanded, about 209 wordsv3 See this version in full on ClinicalTrials.gov ↗
  3. Trial status: Not Yet Recruiting to Recruiting Study sites: 0 to 1 · Start date changed from estimate of Apr 2022 to Apr 7, 2022v2 Show 2 more changesShow less
    • Study sites: 0 to 1
    • Start date changed from estimate of Apr 2022 to Apr 7, 2022
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify; and (4) understand the age-related differences in CPSP. Ultimately, an improved comprehension of mechanisms linked to CPSP will provide finer tools for optimizing the selection of treatments for individual patients. Moreover, data that demonstrates the underlying pathobiological pain mechanism(s) active in CPSP, particularly those non-responsive to current therapies, may be used to validate novel strategies both pharmacological and non-pharmacological.
Trial Details
NCT Number NCT05304286
Lead Sponsor Massachusetts General Hospital
Conditions Chronic Post-surgical Pain
Enrollment 110 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov