Clinical Trial

VIBRANT: VIB4920 for Active Lupus Nephritis

Study acronym: VIBRANT
Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
This is a multi-center double-blind placebo controlled clinical trial evaluating the efficacy of VIB4920 combined with mycophenolate mofetil (MMF) and prednisone in achieving a renal response in participants with active lupus nephritis (LN).
Protocol Amendment History 19 amendments
This ClinicalTrials.gov record has been amended 19 times since 2022-01-07; most recent amendment 2025-12-17.
Status change: Active, Not Recruiting → Recruiting 2024-06-05
Status change: Recruiting → Active, Not Recruiting 2023-10-13
Status change: Not Yet Recruiting → Recruiting 2022-06-06
Trial Details
NCT Number NCT05201469
Lead Sponsor National Institute of Allergy and Infectious Diseases (NIAID)
Conditions Lupus Nephritis
Enrollment 74 participants
Start Date 2022-05-16
Primary Completion 2026-08 (estimated)
Study Completion 2027-03 (estimated)
Updated on ClinicalTrials.gov 2025-12-19