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Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors

Study acronym: IAMFIT
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated December 4, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

See every version on ClinicalTrials.gov ↗

  1. Eligibility criteria expanded, about 4 wordsv18
  2. Re-verified, no change to tracked fieldsv17
  3. Eligibility criteria expanded, about 12 wordsv16
  4. Site details revised at 1 of 3 sitesv15
  5. Start date: Mar 21, 2023 to Feb 23, 2023
    • Site contacts updated at 1 of 3 sites
    v14
Show 12 earlier versionsHide 12 earlier versions
  1. Eligibility criteria shortened, about 1 wordv13
  2. Eligibility criteria expanded, about 12 words
    • Site contacts updated at 1 of 3 sites
    v12
  3. Study sites: 2 to 3
    • Start date: Feb 23, 2023 to Mar 21, 2023
    • Eligibility criteria expanded, about 60 words
    v11
  4. Eligibility criteria expanded, about 5 wordsv10
  5. Start date changed from estimate of Feb 1, 2023 to Feb 23, 2023v9
  6. Start date: Nov 18, 2022 to Feb 1, 2023
    • Eligibility criteria shortened, about 98 words
    v8
  7. Site details revised at 1 of 2 sitesv7
  8. Start date: Oct 18, 2022 to Nov 18, 2022
    • Eligibility criteria expanded, about 5 words
    v6
  9. Start date: Jun 30, 2022 to Oct 18, 2022v5
  10. Trial status: Not Yet Recruiting to Recruiting
    • Site details revised at 2 of 2 sites
    v4
  11. Start date: Apr 30, 2022 to Jun 30, 2022v3
  12. Start date: Jan 31, 2022 to Apr 30, 2022v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This will be a randomized, placebo-controlled trial with a 2x2 factorial design testing the effects of an NAD+ precursor (NR) and exercise on skeletal muscle quality and VO2max in AYA HCT survivors. The primary outcome is the change in muscle strength (isometric knee extension) from baseline to 16 weeks. Key secondary outcomes are the change in muscle strength (ankle plantarflexion) from baseline to 16 weeks, the change in grip strength from baseline to 16 weeks, the change in lower extremity muscle mass from baseline to 16 weeks, the change in muscle OXPHOS capacity from baseline to 16 weeks, and the change in aerobic capacity (VO2 max) from baseline to 16 weeks.
Trial Details
NCT Number NCT05194397
Lead Sponsor Children's Hospital of Philadelphia
Collaborators: National Institutes of Health (NIH), City of Hope Medical Center, St. Jude Children's Research Hospital, National Cancer Institute (NCI), University of Pennsylvania
Conditions
(from sponsor)		 Lymphoblastic Leukemia, Cancer Survivors, Aplastic Anemia, Myelodysplastic Syndromes, Myeloid Leukemia
Related terms Anemia, Aplastic, Leukemia, Myeloid, Myelodysplastic Syndromes, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Sarcopenia
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov