Clinical Trial

Precision Radiation Treatment for Epilepsy (PRECISION)

Study acronym: PRECISION
Active, Not Recruiting
View on ClinicalTrials.gov →
Summary
The PRECISION-study offers a non-invasive, curative intervention for drug-resistant localised epilepsy patients who are not eligible for surgery. The intervention will consist of a single LINAC based SRT treatment and is given by the radiation-oncologist after detailed localisation of the epileptogenic zone with the neurologist, radiologist and neurosurgeon. This intervention will make curative-intent treatment possible where this could otherwise not be given and is a non-invasive and non-competitive alternative to epilepsy surgery. It is expected that the health costs for this curative treatment will not exceed standard treatment, such as lifelong medication and neuromodulation.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2022-01-06; most recent amendment 2025-08-11.
Status change: Recruiting → Active, Not Recruiting 2025-08-11
Status change: Not Yet Recruiting → Recruiting 2024-05-16
Trial Details
NCT Number NCT05182437
Lead Sponsor Maastricht Radiation Oncology
Collaborators: Maastricht University Medical Center, UMC Utrecht, Amsterdam University Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development
Conditions Epilepsy
Enrollment 94 participants
Start Date 2023-12-01
Primary Completion 2028-01-01 (estimated)
Study Completion 2028-01-01 (estimated)
Updated on ClinicalTrials.gov 2025-08-14