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POHCA Resuscitation: Evaluation of IM Epinephrine

Study acronym: PRIME
StatusRecruiting
PhasePhase 2/3
Started2024-01-08
View on ClinicalTrials.gov ↗

Amendment history

2025-03-07
Study Status, Study Description, Contacts/Locations v4
Study sitescontacts updated at 1 of 1 site
2024-02-23
Not Yet Recruiting→Recruiting Study Status, Study Description, Study Design, Arms and Interventions, Contacts/Locations v3
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2025-01→2028-01
Completion date2026-01→2029-01
Start dateestimated 2023-01→confirmed 2024-01-08
Enrollment target76→284
Study description+45 characters
[...] s include whether the use of IM epinephrine via autoinjector and/or pre-filled syringe leads to faster administration of the initial doses of epin [...] first to examine the role of IM epinephrine via autoinjector/pre-filled syringe in POHCA.
Study sitesdetails revised at 1 of 1 site
2022-08-15
Study Status, Arms and Interventions v2
Primary completion date2025-06→2025-01
Completion date2026-06→2026-01
Start date2022-06→2023-01
2022-04-05
Study Status v1
Primary completion date2025-01→2025-06
Completion date2026-01→2026-06
Start date2022-01→2022-06
2021-12-08
Original filing
This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac arrest (POHCA).
Trial Details
NCT Number NCT05166343
Lead Sponsor London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions Pediatric Out-of-Hospital Cardiac Arrest
Enrollment 284 participants
Start Date 2024-01-08
Primary Completion 2028-01 (estimated)
Study Completion 2029-01 (estimated)
Updated on ClinicalTrials.gov 2025-03-11