Clinical Trial

A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia

Study acronym: RELIEF
Recruiting
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Record status
This record was last updated November 21, 2025 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
In 230 patients undergoing mastectomy, the investigators will compare opioid-free anesthesia (OFA) versus conventional opioid-based anesthesia in terms of chronic pain. The enrolled patients will be randomly assigned into two groups with 1:1 ratio. Chronic pain will be evaluated at 1 year after mastectomy based on the Breast Cancer Pain Questionnaire (BCPQ). Baseline pain sensitivity test and psychologic evaluation will be done before operation.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2021-12-02; most recent amendment 2025-11-18.
Trial Details
NCT Number NCT05146778
Lead Sponsor Gangnam Severance Hospital
Conditions Breast Cancer, Mastectomy, Pain, Chronic, Pain, Post Operative
Enrollment 230 participants
Start Date 2021-12-16
Primary Completion 2026-07-31 (estimated)
Study Completion 2027-10-31 (estimated)
Updated on ClinicalTrials.gov 2025-11-21