Accelerated Treatment of Endocarditis

Existing guidelines recommend a duration of antibiotic treatment of endocarditis of 4-6 weeks one or more types of intravenously administered antibiotics. The long hospitalization increases several risks for the patient, including mental strain and increased loss of function. Furthermore, it poses a significant financial burden on the health systems. Current guidelines fail to use available clinical and paraclinical, data collected from patients (echo, temperature, CRP, leukocytes, procalcitonin etc.) to determine duration of treatment. A strategy including these data in treatment algorithms ensures an individualized treatment, targeting the individual patient's course and response to treatment. Thus, the purpose of this open-label, prospective, non-inferiority, RCT study is to investigate the safety and effectiveness of shortening treatment of endocarditis based on the individual patient's initial treatment response, sampling 475 patients, approx. 125 patients with each type of bacteria (Streptococci; Enterococcus faecalis; Staphylococcus aureus). Interim analysis will be conducted when 150 patients have been included, to assess the frequency of the event rate and inclusion rate in order to adjust the intended size of the study population. Due to an administrative error, this study has been registered twice on clinicaltrials.gov under identifiers NCT05144399 (original) and NCT03851575 (duplicate). As per July 2026, both records have been updated to unanimously reflect study status and final protocol. Historical versions of the clinicaltrials.gov registration and updates are available under the respective registration ID's (2018-2020 updates under clinicaltrials.gov registration with ID NCT05144399, 2021-2026 updates clinicaltrials.gov registration with ID NCT03851575).

NCT Number	NCT05144399
Lead Sponsor	Herlev Hospital Collaborators: Nordsjaellands Hospital, Zealand University Hospital, Odense University Hospital, Aarhus University Hospital, Lund University Hospital, Bispebjerg Hospital, Hvidovre University Hospital, Vejle Hospital, Regionshospitalet Viborg, Skive, Brigham and Women's Hospital, Gødstrup Hospital, Rigshospitalet, Denmark
Conditions	Endocarditis
Enrollment	508 participants
Start Date	2019-01-17
Primary Completion	2026-04-28 (estimated)
Study Completion	2036-04-28 (estimated)
Updated on ClinicalTrials.gov	2026-07-23