Clinical Trial

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

Study acronym: TRIDENT
Recruiting
View on ClinicalTrials.gov →
Summary
The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.
Protocol Amendment History 15 amendments
This ClinicalTrials.gov record has been amended 15 times since 2021-11-15; most recent amendment 2026-02-04.
Status change: Not Yet Recruiting → Recruiting 2022-07-11
Trial Details
NCT Number NCT05136703
Lead Sponsor Florida International University
Collaborators: National Institute of Mental Health (NIMH)
Conditions Depression, HIV-1-infection, Inflammation
Enrollment 150 participants
Start Date 2022-08-30
Primary Completion 2027-06-30 (estimated)
Study Completion 2027-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-02-06