Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults

Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.

NCT Number	NCT05108818
Lead Sponsor	University of Pennsylvania Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Stanford University, The Scripps Research Institute
Conditions	Influenza, Human
Enrollment	700 participants
Start Date	2021-10-07
Primary Completion	2027-04-01 (estimated)
Study Completion	2028-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-09