Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository

The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD). The HiRO Hypertrophic Cardiomyopathy registry, biobank and imaging data repository (HiRO-HCM) is a multicenter study that will prospectively enroll patients with HCM as well as those carrying sarcomeric gene variants predisposing to HCM. The objectives of HiRO-HCM are: 1. to better understand the natural history of the disease and identify clinical markers and biomarkers for adverse outcomes; 2. to derive and validate risk prediction models for disease expression, complications and response to therapy; 3. to better define the genetic architecture of sarcomeric and non-sarcomeric HCM.

NCT Number	NCT05100420
Lead Sponsor	Montreal Heart Institute Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions	Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Cardiomyopathies
Enrollment	2,000 participants
Start Date	2021-02-23
Primary Completion	2026-02-23 (estimated)
Study Completion	2027-08-23 (estimated)
Updated on ClinicalTrials.gov	2023-10-30