Clinical Trial

Study to Determine the Antitumor Activity of New CAR-macrophages in Breast Cancer Patients' Derived Organoids

Study acronym: CARMA
Recruiting
View on ClinicalTrials.gov →
Summary
Cell-based immune therapy using modified macrophages is a promising therapeutic approach in breast cancer. The objective of this cohort study is to collect tumor samples to develop patients' derived organoids to test the antitumor activity of newly developed CAR-macrophages. Other biological samples will be collected such as blood to analyze the host inflammatory status.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2021-08-11.
Status change: Not Yet Recruiting → Recruiting 2026-03-16
Trial Details
NCT Number NCT05007379
Lead Sponsor Centre Oscar Lambret
Collaborators: Institut National de la Santé Et de la Recherche Médicale, France
Conditions Breast Cancer
Enrollment 100 participants
Start Date 2021-11-02
Primary Completion 2023-09-01 (estimated)
Study Completion 2027-12-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-18