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Xenon MRI Pulm Hypertension

Study acronym: Jupiter PH
StatusRecruiting
PhasePhase 2
Started2021-09-01
View on ClinicalTrials.gov ↗

Amendment history

2026-08-06
Study Status, Study Design, Contacts/Locations v9
Trial status changed: Terminated → Recruiting
Reason stoppedFunding Ended.→not stated
Primary completion date2025-05-14→2027-07-31
Completion date2025-05-28→2027-07-31
Enrollment target12→20
Study sitesdetails revised at 1 of 1 site
2026-04-15
Recruiting→Terminated Study Status, Oversight, Study Design, Contacts/Locations, Document Section v8
Trial statusRecruiting→Terminated
Reason stoppednot stated→Funding Ended.
Primary completion dateestimated 2026-08-30→confirmed 2025-05-14
Completion dateestimated 2026-08-30→confirmed 2025-05-28
Enrollment targetestimated 60→confirmed 12
Study sitesdetails revised at 1 of 1 site
2025-10-17
Study Status, Contacts/Locations v7
Re-verified, no change to tracked fields
2025-07-21
Study Status, Contacts/Locations v6
Study sitescontacts updated at 1 of 1 site
2024-11-12
Study Status, Oversight, Contacts/Locations v5
Study sitescontacts updated at 1 of 1 site
Show 4 earlier versions
2023-11-10
Study Status v4
Re-verified, no change to tracked fields
2022-11-15
Study Status, Arms and Interventions, Eligibility v3
Eligibility criteria-6 characters
[...] r gender, Age 18-75 Awaiting a lung transplant Diagnosis of Group 1precapillary PH using the criteria from previous clinical trials (right heart catheterization demonstrating hemodynamic crit [...] stance ≥ 3 WU, pulmonary capillary wedge pressure ≤ 15 mmHg) in the setting of Group 1 (PAH), 3 (PH due to chronic lung disease, 4 (PH due to pulmonary artery obstructions), or 5 (PH due to miscellaneous causes) Willing and giving informed consent and adhere to visit/pro [...] th any of the following will not be included in the trials: Pulmonary Veno-occlusive disease or Porto-pulmonary hypertension Moderate to s [...] [...]
2022-05-25
Study Status, Contacts/Locations v2
Study sitescontacts updated at 1 of 1 site
2021-09-21
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2021-08-30→confirmed 2021-09-01
Study sitesdetails revised at 1 of 1 site
2021-07-27
Original filing
The overall objective outlined in this study is to determine how pulmonary vascular remodeling in PAH at a cellular and pathological level is associated with changes in gas exchange physiology and hemodynamics (monitored with 129Xe MRI/MRS) and how these signals change with disease progression or treatment.
Trial Details
NCT Number NCT04991454
Lead Sponsor Bastiaan Driehuys
Conditions Pulmonary Hypertension, Pulmonary Arterial Hypertension
Enrollment 20 participants
Start Date 2021-09-01
Primary Completion 2027-07-31 (estimated)
Study Completion 2027-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-10