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MinorTrial status: Recruiting to CompletedShow 5 more changesShow less
Primary and study completion dates changed from estimate of Sep 2026 to Sep 25, 2026
Eligibility criteria expanded, about 11 words
Study description revised
Site details revised at 2 of 2 sites
Publications: details revised at 22 of 24 entries
MinorRe-verified, no change to tracked fieldsv17
NotablePrimary completion date: Sep 2025 to Sep 2026
Study completion date: Dec 2025 to Sep 2026
v16
MinorRe-verified, no change to tracked fieldsv15
Show 13 earlier versionsHide 13 earlier versions
NotablePhase: Phase 2 to Not applicablev14Show 7 more changesShow less
Lead sponsor: University of California Santa Cruz to Wake Forest University Health Sciences
Primary endpoints: 1 to 2
Interventions: App-Based Contingency Management (Device), Sham Control (Behavioral) to App-Based Contingency Management (Behavioral), Sham Control (Behavioral)
Eligibility criteria revised
Secondary endpoints expanded, about 21 words
Collaborators: 2 to 3
Study title expanded, about 3 words
NotableLead sponsor: Wake Forest University Health Sciences to University of California Santa Cruzv13Show 4 more changesShow less
Primary completion date: Sep 2024 to Sep 2025
Study completion date: Dec 2024 to Dec 2025
Site contacts updated at 1 of 2 sites
Collaborators: 3 to 2
MinorCollaborators reorderedv12
NotablePrimary completion date: Jan 2024 to Sep 2024
Study completion date: Jun 2024 to Dec 2024
v11
NotablePrimary completion date: Jun 2023 to Jan 2024v10
MinorRe-verified, no change to tracked fieldsv9
MinorStudy sites revised (2)v8
NotablePhase: Phase 3 to Phase 2
Interventions: App-Based Contingency Management (Behavioral), Sham Control (Behavioral) to App-Based Contingency Management (Device), Sham Control (Behavioral)
v7
MinorRe-verified, no change to tracked fieldsv6
MinorStudy description shortened, about 191 words
Study arms: 5 to 7
Eligibility criteria expanded, about 5 words
v5
NotablePrimary endpoints: 3 to 1
Secondary endpoints shortened, about 9 words
v4
NotableTrial status: Not Yet Recruiting to Recruiting
Study sites: 0 to 2
Start date: Aug 2021 to Sep 15, 2021
v3
MinorStudy description revisedv2
MinorStudy First Submitted
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive payments for healthy behaviors. This approach, broadly known as "contingency management" in the medical literature, has repeatedly shown to be effective in treating substance abuse. However, the use of incentives by treatment facilities remains extremely low. Furthermore, it is not well understood how to design optimal incentives to treat opioid abuse. This project will conduct a randomized evaluation of two types of dynamically adjusting incentive schedules for people with opioid use disorders or cocaine use disorders: "escalating" schedules where incentive amounts increase with success to increase incentive power, and "de-escalating" schedules where incentive amounts decrease with success to improve incentive targeting. Both schemes are implemented with a novel "turnkey" mobile application, making them uniquely low-cost, low-hassle, and scalable. Effects will be measured on abstinence outcomes, including longest duration of abstinence and the percentage of negative drug tests. In combination with survey data, variation from the experiment will shed light on the barriers to abstinence more broadly and inform the understanding of optimal incentive design.