Screening Donors, Fecal Microbiota Transplant Program in Ulcerative Colitis

The investigators intend to screen for new donors, given that there may a donor effect (PubMed ID: 25857665), with some donors not inducing remission in any patient whilst others inducing remission in 20-40% of cases. It is important to give UC patients participating in RCTs stool that has been demonstrated to be effective in some patients. We therefore propose to conduct an open label study in patients with active UC to ensure new donors are effective at inducing remission in some patients. Patients that have FMT will relapse within 18 months (PubMed ID: 25857665) although further FMT therapy induces remission so it is possible that maintenance FMT will result in long term remission, but this needs evaluation. We will therefore follow UC patients that have responded to FMT long term in this open label study.

NCT Number	NCT04926103
Lead Sponsor	Hamilton Health Sciences Corporation Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions	Ulcerative Colitis Flare
Enrollment	200 participants
Start Date	2022-07-01
Primary Completion	2028-10-01 (estimated)
Study Completion	2029-05-01 (estimated)
Updated on ClinicalTrials.gov	2024-10-01