Clinical Trial

Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

Study acronym: TRUST
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered gout outcomes, as well as relevant cardiovascular-metabolic-renal endpoints.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2021-05-03; most recent amendment 2025-09-22.
Status change: Not Yet Recruiting → Recruiting 2024-03-12
Trial Details
NCT Number NCT04875702
Lead Sponsor Massachusetts General Hospital
Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conditions Gout
Enrollment 650 participants
Start Date 2024-02-22
Primary Completion 2028-09-01 (estimated)
Study Completion 2028-10-31 (estimated)
Updated on ClinicalTrials.gov 2025-09-25