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Neural Correlates of Real World Spatial Navigation in Humans

StatusRecruiting
PhaseNot applicable
Started2020-09-30
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 12 months later Jun 30, 2026 → Jun 30, 2027
See other at-risk trials from Duke University

Amendment history

2026-09-23
Primary completion pushed: 2026-06-30 → 2027-06-30
Completion pushed: 2026-06-30 → 2027-06-30
2026-05-13
Study Identification, Study Status, Sponsor/Collaborators, Oversight, Study Design, Arms and Interventions, Contacts/Locations, IPDSharing v7
Study sites1→2
Study arms0→1
Lead sponsorUniversity of California, Los Angeles→Duke University
InterventionsDeep Brain Stimulation (Device)→Deep Brain Stimulation (Device), Memory and spatial navigation tasks (Behavioral), Physiological Signals (Behavioral), Questionnaires and…
Collaborators1 to 2 entries
National Institute of Mental Health (NIMH)
2025-07-22
Study Status v6
Primary completion date2025-06-30→2026-06-30
Completion date2025-06-30→2026-06-30
2025-04-23
Study Status, Oversight, Eligibility, Contacts/Locations v5
Eligibility criteria-29 characters
Inclusion Criteria: 1812 years of age or older and has undergone RNS system placemen [...] ly Exclusion Criteria: Unwilling to provide informed consent Not a native English Speaker
Study sitescontacts updated at 1 of 1 site
2025-03-11
Study Status, Oversight, Contacts/Locations v4
Study sitescontacts updated at 1 of 1 site
Show 3 earlier versions
2024-04-24
Study Status v3
Primary completion date2024-06-30→2025-06-30
2023-05-08
2 amendments v1-v2
2 re-verifications since 2022-05-16, no change to tracked fields
2021-04-30
Original filing
Duke University
455 trials monitored
See 53 trials at risk
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Trial Details
NCT Number NCT04874220
Lead Sponsor Duke University
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH)
Conditions Memory, Delayed
Enrollment 70 participants
Start Date 2020-09-30
Primary Completion 2027-06-30 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-09-28