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Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis

StatusCompleted
PhasePhase 4
Started2021-07-19
View on ClinicalTrials.gov ↗

Amendment history

2026-09-23
Trial completed
Final enrollment: 15 participants (planned 27)
Primary completion 2026-09-01, at least 365 days after the final estimate of 2025-09-01
2024-12-18
Study Status, Contacts/Locations v6
Primary completion date2024-09-01→2025-09-01
Completion date2024-12-01→2025-12-01
2024-04-04
Study Status v5
Primary completion date2024-01→2024-09-01
Completion date2024-06→2024-12-01
2023-09-22
Study Status v4
Primary completion date2023-01→2024-01
Completion date2023-06→2024-06
2022-08-21
Study Status v3
Re-verified, no change to tracked fields
Show 2 earlier versions
2021-07-20
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2021-06→confirmed 2021-07-19
Study sites0→1
2021-05-02
Study Status, Sponsor/Collaborators v1
Re-verified, no change to tracked fields
2021-04-28
Original filing
The study aims to investigate the olfactory TDI score (Threshold, Discrimination, Identification) using the Sniffin' sticks test for patients with chronic rhinosinusitis with nasal polyps (CRSwNP) on dupilumab. Twenty-seven adult patients will be followed up during the treatment with dupilumab on three visits to the Otolaryngology Clinic (Baseline, 3 months and 6 months). The primary endpoint will be the TDI score. Nasal polyp score, Quality of Olfactory Disorders - negative symptoms (QOD-NS symptom scores), SNOT-22 will be secondary endpoints.
Trial Details
NCT Number NCT04869436
Lead Sponsor London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborators: Mount Sinai Hospital, Canada
Conditions Chronic Rhinosinusitis With Nasal Polyps, Olfactory Disorder
Enrollment 15 participants
Start Date 2021-07-19
Primary Completion 2026-09-01 (estimated)
Study Completion 2026-09-16 (estimated)
Updated on ClinicalTrials.gov 2026-09-22