Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis

StatusEnrolling by Invitation
PhaseNot applicable
Started

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Trial flagged as At Risk
Primary completion moved at least 3 months later Jun 30, 2027 → Sep 30, 2027
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Record History

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  1. Primary completion pushed from Jun 30, 2027 to Sep 30, 2027
    • Eligibility criteria expanded, about 18 words
    • Publications: details revised at 21 of 21 entries
  2. Enrollment target: 40 to 14
    • Primary completion date: Dec 31, 2033 to Jun 30, 2027
    • Study completion date: Dec 31, 2033 to Jun 30, 2028
    • Study arms: 4 to 3
    v8
  3. Re-verified, no change to tracked fieldsv7
  4. Eligibility criteria expanded, about 1 wordv6
  5. Re-verified, no change to tracked fieldsv5
Show 3 earlier versionsHide 3 earlier versions
  1. Trial status: Recruiting to Enrolling by Invitation
    • Site details revised at 3 of 3 sites
    v4
  2. Start date: Apr 28, 2021 to Aug 1, 2021v3
  3. Start date: Apr 14, 2021 to Apr 28, 2021v2
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and functional brain changes in general, and hippocampal plasticity more specifically relative to the shorter 6-month and 2-month missions.
Trial Details
NCT Number NCT04856410
Lead Sponsor University of Pennsylvania
Collaborators: National Aeronautics and Space Administration (NASA), DLR German Aerospace Center, Charite University, Berlin, Germany
Conditions
(from sponsor)		 Brain Structure, Cognitive Performance
Enrollment 14 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov