Remote Ischaemic Conditioning in STEMI Patients in AFRICA

The RIC-AFRICA trial is a multi-centre, sham-controlled, randomised controlled trial (RCT) involving 1400 ST-segment elevation myocardial infarction (STEMI) patients presenting within ≤ 24 hours of myocardial infarction (MI) onset, across approximately 25 sites in 7 African countries (South Africa, Kenya, Sudan, Uganda, Mozambique, Senegal and Mauritius). Patients presenting with STEMI and deemed ineligible for the RIC AFRICA RCT because they present \>24 hours from MI onset but less than 72 hours, will be recruited into the observational arm of the study with the same endpoints as the trial. The purpose of the RCT is to determine whether Remote Ischaemic Conditioning (RIC) can reduce the rates of all-cause death and early post-myocardial heart failure at 30-days in STEMI patients treated predominantly with thrombolytic therapy.

NCT Number	NCT04813159
Lead Sponsor	University of Cape Town Collaborators: Groote Schuur Hospital, South Africa, Uganda Heart Institute, Mombasa Hospital, Kenya, Coast General Teaching Hospital, Kenya, Kenyatta National Hospital, Al Shaab Teaching Hospital, Sudan, Sudan Heart Centre, Sudan, Aliaa Specialist Hospital, Sudan, Medani Heart Centre, Sudan, Al Saha Specialised Hospital, Sudan, Omdurman Hospital, Sudan, Victoria Hospital, South Africa, George Hospital, South Africa, Charlotte Maxeke Hospital, South Africa, Tshepong Hospital, South Africa, Wentworth Hospital, South Africa, Grey's Hospital, Universitas Academic Hospital, South Africa, University College, London, Royal Care international Hospital, Sudan, Nairobi West Hospital, Kenya
Conditions	STEMI, Remote Ischaemic Conditioning, Myocardial Reperfusion Injury
Enrollment	1,400 participants
Start Date	2022-01-12
Primary Completion	2027-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-04-03