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Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

The 50 most recent of 201 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. 8 versions Re-verified since Oct 16, 2025, no change to tracked fieldsv194-v201
  2. Eligibility criteria expanded, about 10 wordsv193
  3. Re-verified, no change to tracked fieldsv192
  4. Eligibility criteria shortened, about 3 words
    • Study description shortened, about 1 word
    v191
  5. 2 versions Re-verified since Jun 5, 2025, no change to tracked fieldsv189-v190
Show 37 earlier versionsHide 37 earlier versions
  1. Study description expanded, about 18 wordsv188
  2. Re-verified, no change to tracked fieldsv187
  3. Eligibility criteria expanded, about 22 words
    • Study description revised
    v186
  4. Eligibility criteria shortened, about 11 wordsv185
  5. 6 versions Re-verified since Nov 22, 2024, no change to tracked fieldsv179-v184
  6. Eligibility criteria shortened, about 30 words
    • Study description expanded, about 1 word
    v178
  7. 4 versions Re-verified since Jul 24, 2024, no change to tracked fieldsv174-v177
  8. Study description expanded, about 24 wordsv173
  9. 2 versions Re-verified since May 18, 2024, no change to tracked fieldsv171-v172
  10. Primary and study completion dates: Jun 30, 2025 to Jun 30, 2027v170
  11. 3 versions Re-verified since Mar 21, 2024, no change to tracked fieldsv167-v169
  12. Eligibility criteria expanded, about 57 wordsv166
  13. Re-verified, no change to tracked fieldsv165
  14. Eligibility criteria expanded, about 51 wordsv164
  15. Eligibility criteria expanded, about 45 words
    • Study description revised
    v163
  16. 4 versions Re-verified since Apr 10, 2023, no change to tracked fieldsv159-v162
  17. Study description expanded, about 41 wordsv158
  18. Primary and study completion dates: Jun 30, 2024 to Jun 30, 2025v157
  19. Primary completion date: Jun 1, 2023 to Jun 30, 2024
    • Study completion date: Jun 30, 2023 to Jun 30, 2024
    v156
  20. 4 versions Re-verified since Jul 1, 2022, no change to tracked fieldsv152-v155
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental syndrome. Researchers think brain development may be controlled by gamma-aminobutyric acid (GABA). They want to learn how abnormalities in the GABA system may contribute to ASD. Objective: To see if repetitive transcranial magnetic stimulation (rTMS) creates short-term changes in how different parts of the brain communicate. Eligibility: Right-handed people ages 11-17 with ASD, and healthy volunteers ages 18-25. Design: Participants will be screened with: Medical history Physical exam Medicine review Neurological exam Psychological tests and rating scales Forms and surveys. Participants will have a hearing test and ear exam. Participants will have magnetic resonance imaging (MRI) of the brain. They will lie on a table that moves in and out of the MRI scanner. They may look at a screen while in the scanner. A coil will be placed over their head. Participants will have magnetic resonance spectroscopy. It takes pictures of chemicals in the brain using the MRI scanner. Participants will have magnetoencephalography. They will sit in a chair. A helmet with magnetic field sensors will be placed on their head. Participants will have TMS. A wire coil will be held on their scalp. A brief electrical current will pass through the coil. Participants will have electromyography. Sticky pad electrodes will be placed on the skin during TMS. The electrical activity of their muscles will be measured. Participants will have rTMS. It uses short bursts of magnetic pulses to affect brain activity. ASD participants may have visits scheduled as often as 1 time a week or as far apart as 2 months based on the participants or study team's availability. Healthy volunteers will have 3 visits over 3-4 weeks....
Trial Details
NCT Number NCT04798274
Lead Sponsor National Institute of Mental Health (NIMH)
Conditions
(from sponsor)		 Autism Spectrum Disorder
Related terms Autism Spectrum Disorder, Language
Enrollment 106 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov