AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE

The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF). The primary objective of the study is to evaluate the efficacy of Aspirin versus Aspirin + Clopidogrel after LAAC by comparing the occurrence of ischemic lesions on cerebrovascular magnetic resonance imaging (MRI) studies.

NCT Number	NCT04796714
Lead Sponsor	University Hospital, Bordeaux
Conditions	Atrial Fibrillation, Atrial Appendage, Anticoagulants, Stroke, Platelet Aggregation Inhibitors
Enrollment	60 participants
Start Date	2022-10-03
Primary Completion	2027-05-03 (estimated)
Study Completion	2027-05-03 (estimated)
Updated on ClinicalTrials.gov	2026-06-10