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Sequential Neoadjuvant Chemotherapy in Soft Tissue Sarcoma

StatusRecruiting
PhasePhase 2
Started2021-04-27
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 14, 2025 (before its estimated September 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2025-08-11
Study Status v6
Re-verified, no change to tracked fields
2024-04-12
Study Status v5
Primary completion date2024-09→2026-09
Completion date2034-09→2036-09
2022-11-01
Study Status, Contacts/Locations v4
Study sitesdetails revised at 1 of 2 sites
2022-09-20
Study Status v3
Re-verified, no change to tracked fields
2021-09-10
Study Status, Contacts/Locations v2
Start dateestimated 2021-03→confirmed 2021-04-27
Study sitescontacts updated at 1 of 2 sites
2021-03-15
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Study sitesdetails revised at 2 of 2 sites
2021-02-26
Original filing
Nearly half of patients with high-grade, localized soft tissue sarcoma (STS) of extremities and trunk wall develop disease recurrence after local therapy. Adjuvant chemotherapy with ifosfamide and doxorubicin may improve long-term disease-free survival, but the benefit of adjuvant treatment is limited and predictive factors for treatment response are lacking. The aim of this study is to explore sequential treatment with ifosfamide and doxorubicin in a neoadjuvant setting and to investigate biomarkers predictive of treatment response.
Trial Details
NCT Number NCT04776525
Lead Sponsor Oslo University Hospital
Collaborators: Haukeland University Hospital
Conditions Soft Tissue Sarcoma
Enrollment 49 participants
Start Date 2021-04-27
Primary Completion 2026-09 (estimated)
Study Completion 2036-09 (estimated)
Updated on ClinicalTrials.gov 2025-08-14