Clinical Trial

Early Life Stress and Depression: Molecular and Functional Imaging

Study acronym: ELS
Recruiting
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Record status
This record was last updated December 12, 2025 (before its estimated June 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
Severe childhood adversity accounts for a large portion of psychiatric illness, and an increased risk for major depressive disorder (MDD). For some individuals, childhood adversity has negative psychological and medical consequences; others preserve mental and physical health despite such experiences (they are resilient). In spite of this, little is known about the neurobiological mechanisms related to childhood adversity, especially oxidative stress abnormalities in the brain. To fill this gap, this study combines functional, structural, and molecular imaging approaches to examine the role of oxidative stress abnormalities related to childhood adversity.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2021-01-14; most recent amendment 2025-12-04.
Status change: Not Yet Recruiting → Recruiting 2021-03-10
Trial Details
NCT Number NCT04713722
Lead Sponsor Mclean Hospital
Conditions Depression, Trauma, Psychological
Enrollment 160 participants
Start Date 2021-02-01
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-12-12