Timing of FFR-guided PCI for Non-IRA in STEMI and MVD (OPTION-STEMI)

Patients with STEMI (ST-segment elevation myocardial infarction) with multivessel disease which have PCI (percutaneous coronary intervention)-suitable non-IRA (infarct related artery) will be randomized to immediate complete revascularization group or staged revascularization group by 1:1 fashion. Non-IRA lesion which have equal or more than 70% diameter stenosis by visual estimation will be revascularized without FFR (fractional flow reserve) evaluation. Non-IRA lesion with diameter stenosis 50-70% by visual estimation will be evaluated using FFR device. In case of FFR value more than 0.8, non-IRA lesion wll be deferred without PCI. If FFR value was equal or less than 0.8, non-IRA lesion will be revascularized.

NCT Number	NCT04626882
Lead Sponsor	Chonnam National University Hospital
Conditions	Myocardial Infarction, Acute, Multi-Vessel Coronary Artery Stenosis
Enrollment	994 participants
Start Date	2019-12-30
Primary Completion	2025-01-15 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-07