Clinical Trial

Pharmacological and Behavioral Treatments After Bariatric Surgery: Maintenance Treatment (Stage 2a)

Active, Not Recruiting Phase 2/3
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Summary
This study will test the effectiveness of naltrexone/bupropion medication as a maintenance therapy for the treatment of loss-of-control eating and weight loss following bariatric surgery. This is a controlled test of whether, amongst responders to acute treatments, naltrexone/bupropion medication results in superior maintenance and longer-term outcomes compared with placebo.
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2020-10-21; most recent amendment 2026-01-26.
Status change: Enrolling by Invitation → Active, Not Recruiting 2026-01-26
Status change: Not Yet Recruiting → Enrolling by Invitation 2022-05-25
Trial Details
NCT Number NCT04605081
Lead Sponsor Yale University
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions Loss-of-Control Eating, Obesity/Overweight
Enrollment 100 participants
Start Date 2022-01-10
Primary Completion 2027-05 (estimated)
Study Completion 2027-05 (estimated)
Updated on ClinicalTrials.gov 2026-01-27