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Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women

Study acronym: FiRST
StatusActive, Not Recruiting
PhaseNot specified
Started2019-04-19
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 27 months later Apr 10, 2026 → Aug 2028
See other at-risk trials from Yale University

Amendment history

2026-09-01
Study Status, IPDSharing v6
Trial status changed: Enrolling by Invitation → Active, Not Recruiting
Primary completion pushed: 2026-04-10 → 2028-08
Completion moved earlier: 2029-04-30 → 2028-08
2025-11-03
Study Status v5
Primary completion date2025-04-19→2026-04-10
Completion date2025-04-19→2029-04-30
2025-01-07
Study Status v4
Re-verified, no change to tracked fields
2023-10-10
Study Status v3
Primary completion date2023-04-19→2025-04-19
Completion date2023-04-19→2025-04-19
2022-11-09
2 amendments v1-v2
2 re-verifications since 2021-11-01, no change to tracked fields
2020-10-16
Original filing
Yale University
487 trials monitored
See 35 trials at risk
A real world study to evaluate outcomes in women based on guideline identified fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) cutoffs for ischemia (ischemia defined as FFR ≤ 0.80 and iFR ≤ 0.89).
Trial Details
NCT Number NCT04599192
Lead Sponsor Yale University
Conditions Coronary Disease, Percutaneous Coronary Intervention, Exercise Test, Myocardial Perfusion Imaging, Cardiac Catheterization
Enrollment 500 participants
Start Date 2019-04-19
Primary Completion 2028-08 (estimated)
Study Completion 2028-08 (estimated)
Updated on ClinicalTrials.gov 2026-09-04