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Corneal Biomechanical Analysis Using Brillouin Microscopy

StatusEnrolling by Invitation
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 11 months later Jul 2026 → Jul 2027
See other at-risk trials from The Cleveland Clinic

Record History

See every version on ClinicalTrials.gov ↗

  1. Notable Primary completion pushed from Jul 2026 to Jul 2027 Show 4 more changesShow less
    • Study completion pushed from Dec 2026 to Dec 2027
    • Eligibility criteria expanded, about 8 words
    • Study description revised
    • Publications: details revised at 7 of 7 entries
  2. Minor Re-verified, no change to tracked fieldsv9
  3. Notable Primary completion date: Jul 2025 to Jul 2026
    • Study completion date: Dec 2025 to Dec 2026
    • Publications: details revised at 4 of 7 entries
    v8
  4. Notable Primary completion date: Jul 2024 to Jul 2025
    • Study completion date: Dec 2024 to Dec 2025
    • Publications: details revised at 4 of 7 entries
    v7
  5. Minor Re-verified, no change to tracked fieldsv6
Show 4 earlier versionsHide 4 earlier versions
  1. Notable Primary completion date: Jul 2022 to Jul 2024
    • Study completion date: Dec 2022 to Dec 2024
    • Collaborator revised
    v5
  2. Notable Trial status: Not Yet Recruiting to Enrolling by Invitation
    • Study sites: 0 to 1
    • Start date changed from estimate of Jun 2021 to Jun 1, 2021
    v4
  3. Notable Start date: Feb 2021 to Jun 2021v3
  4. Notable Start date: Dec 2020 to Feb 2021v2
  1. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The objective of this study is to measure the Brillouin biomechanical properties in keratoconic corneas and characterize biomechanical alterations that occur after corneal procedures that inherently strengthen or weaken the cornea by evaluating the change in Brillouin metrics before and after treatments.
Trial Details
NCT Number NCT04598932
Lead Sponsor The Cleveland Clinic
Collaborators: University of Maryland
Conditions
(from sponsor)
Keratoconus, Keratoconus, Unstable, Keratoconus, Stable
Related terms Keratoconus
Enrollment 220 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov