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Study of XGEVA® (Denosumab) in Chinese Adults and Skeletally Mature Adolescents With Giant Cell Tumor of the Bone

StatusActive, Not Recruiting
PhasePhase 4
SponsorAmgen
Started2023-08-17
View on ClinicalTrials.gov ↗
The study aims to evaluate the efficacy of XGEVA® in Chinese participants with giant cell tumor of bone (GCTB).

Amendment record

Amended 23 times since 2020-10-07; most recent filed 2025-09-30. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-31.

2025-09-30
Amendment Study Status v23
2025-05-05
Amendment Study Status v22
2025-03-21
Amendment Recruiting→Active, Not Recruiting Study Status, Study Design, Contacts/Locations v21
2024-10-15
Amendment Study Status v20
2024-09-19
Amendment Study Status v19
2024-08-08
Amendment Study Status, Contacts/Locations v18
2024-06-19
Amendment Study Status, Contacts/Locations v17
2024-02-07
Amendment Study Status, Contacts/Locations v16
2024-01-03
Amendment Study Status, Contacts/Locations v15
2023-10-16
Amendment Study Status v14
2023-09-06
Amendment Study Status, Contacts/Locations v13
2023-08-29
Amendment Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v12
2023-08-04
Amendment Study Status, Contacts/Locations v11
2023-06-28
Amendment Study Status, Contacts/Locations v10
2023-05-31
Amendment Study Status v9
2023-05-18
Amendment Study Status v8
2023-04-24
Amendment Study Status, Contacts/Locations v7
2023-03-01
Amendment Study Status v6
2022-03-03
Amendment Study Status v5
2021-12-02
Amendment Study Status v4
2021-10-13
Amendment Study Status v3
2020-11-27
Amendment Study Status v2
2020-10-28
Amendment Study Status, Arms and Interventions, Outcome Measures v1
2020-10-07
Original filing
Trial Details
NCT Number NCT04586660
Lead Sponsor Amgen
Conditions Giant Cell Tumor of Bone
Enrollment 36 participants
Start Date 2023-08-17
Primary Completion 2028-03-07 (estimated)
Study Completion 2028-03-07 (estimated)
Updated on ClinicalTrials.gov 2025-10-01