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Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's Disease

Study acronym: BEAN
StatusRecruiting
PhasePhase 3
SponsorAmgen
Started2021-09-09
View on ClinicalTrials.gov ↗
The aim of this study is to estimate the efficacy of apremilast compared to placebo in the treatment of oral ulcers in pediatric participants from 2 to \< 18 years of age with oral ulcers associated with Behçet's disease (BD) through week 12.

Amendment record

Amended 30 times since 2020-08-24; most recent filed 2026-07-22. Every amendment is listed below.

Dates here are the day the sponsor filed the amendment, not the day ClinicalTrials.gov published it. Version history last read from ClinicalTrials.gov on 2026-08-29.

2026-07-22
Amendment Study Status, Contacts/Locations v30
2025-11-26
Amendment Study Status, Contacts/Locations v29
2025-10-22
Amendment Study Status, Contacts/Locations v28
2025-06-17
Amendment Study Identification, Study Status, Study Design, Outcome Measures, Eligibility, Contacts/Locations v27
2024-11-15
Amendment Study Identification, Study Status, Contacts/Locations v26
2024-09-13
Amendment Study Identification, Study Status, Contacts/Locations v25
2023-12-06
Amendment Study Status, Contacts/Locations v24
2023-11-22
Amendment Study Status, Contacts/Locations v23
2023-10-10
Amendment Study Status v22
2023-08-16
Amendment Study Status, Contacts/Locations v21
2023-08-02
Amendment Study Status, Contacts/Locations v20
2023-07-19
Amendment Study Status, Contacts/Locations v19
2023-07-05
Amendment Study Status, Contacts/Locations v18
2023-06-21
Amendment Study Status, Contacts/Locations v17
2023-04-24
Amendment Study Status, Contacts/Locations v16
2022-11-07
Amendment Study Status, Contacts/Locations v15
2022-09-01
Amendment Study Status, Contacts/Locations v14
2022-08-11
Amendment Study Status, Contacts/Locations v13
2022-06-29
Amendment Study Status, Contacts/Locations v12
2022-03-09
Amendment Study Status, Contacts/Locations v11
2022-03-02
Amendment Study Status, Contacts/Locations v10
2022-02-17
Amendment Study Status, Contacts/Locations v9
2022-01-10
Amendment Study Status, Outcome Measures, Eligibility, Contacts/Locations v8
2021-11-10
Amendment Study Status, Contacts/Locations v7
2021-10-20
Amendment Study Status, Contacts/Locations v6
2021-10-14
Amendment Study Status, Contacts/Locations v5
2021-09-20
Amendment Not Yet Recruiting→Recruiting Study Status, Oversight, Contacts/Locations v4
2021-07-13
Amendment Study Status v3
2020-11-30
Amendment Study Status v2
2020-09-08
Amendment Study Status, Conditions, Outcome Measures v1
2020-08-24
Original filing
Trial Details
NCT Number NCT04528082
Lead Sponsor Amgen
Conditions Behçet Disease
Enrollment 60 participants
Start Date 2021-09-09
Primary Completion 2030-02-07 (estimated)
Study Completion 2030-12-17 (estimated)
Updated on ClinicalTrials.gov 2026-07-24