Clinical Trial

Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas

Recruiting Phase 2
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Record status
This record was last updated March 28, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.
Protocol Amendment History 9 amendments
This ClinicalTrials.gov record has been amended 9 times since 2020-08-05; most recent amendment 2025-03-24.
Status change: Not Yet Recruiting → Recruiting 2021-02-04
Trial Details
NCT Number NCT04506008
Lead Sponsor Vanderbilt-Ingram Cancer Center
Conditions Soft Tissue Sarcomas
Enrollment 40 participants
Start Date 2021-03-02
Primary Completion 2026-06 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2025-03-28