Clinical Trial

Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

Recruiting Phase 1/2
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Record status
This record was last updated July 20, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.
Summary
The study proposes to develop a phenylephrine protocol to be used during transesophageal echocardiography, whereby intravenous phenylephrine would be used to increase afterload with the intent to mimic the awake hemodynamic profile and variation that occurs with normal physical activity. The expectation is to see changes in severity of Mitral Regurgitation (MR) grade with increasing afterload, which in turn can provide more accurate quantification of MR severity to assist in clinical decision making.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2020-08-03; most recent amendment 2025-07-16.
Status change: Not Yet Recruiting → Recruiting 2021-03-19
Trial Details
NCT Number NCT04500899
Lead Sponsor Montefiore Medical Center
Collaborators: Baylor College of Medicine
Conditions Mitral Regurgitation
Enrollment 35 participants
Start Date 2020-12-01
Primary Completion 2026-06 (estimated)
Study Completion 2026-06 (estimated)
Updated on ClinicalTrials.gov 2025-07-20