Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection

The purpose of this study is to evaluate how useful vitamin D supplementation is in reducing the severity of COVID-19 symptoms and the body's inflammatory and infection-fighting response to COVID-19. Individuals ≥50 years of age and older who are tested for COVID-19 and negative will be randomized (like flipping a coin) to either daily high dose vitamin D supplementation (6000 IU vitamin D3/day) vs. standard of care. Those individuals ≥50 years of age or older who test positive for COVID-19 at baseline will be randomized to bolus vitamin D (20,000 IU/day for 3 days) followed by high dose (6000 IU vitamin D/day) vs. standard of care for 12 months. All participants will receive a multivitamin containing vitamin D.

NCT Number	NCT04482673
Lead Sponsor	Medical University of South Carolina Collaborators: Grassroots Health Nutrition Institute, ZRT Laboratory
Conditions	COVID-19, Vitamin D Deficiency, Respiratory Viral Infection
Enrollment	95 participants
Start Date	2020-07-31
Primary Completion	2022-12-31 (estimated)
Study Completion	2023-12-31 (estimated)
Updated on ClinicalTrials.gov	2023-02-24